Polymorphism and tautomeric preference in fenobam and the utility of NLO response to detect polymorphic impurities.
نویسندگان
چکیده
Crystal structures of polymorphs and solvatomorphs of the potential anxiolytic drug fenobam exhibit an exclusive preference for one of the two possible tautomeric structures. A novel methodology based on nonlinear optical response has been successfully employed to detect the presence of a polymorphic impurity in a mixture of polymorphs.
منابع مشابه
Change of the tautomeric preference for radical cation of pyruvic acid. DFT studies in the gas phase
Keto-enol tautomerism was investigated for ionized pyruvic acid using the DFT(B3LYP) method and the larger basis sets [6-31++G(d,p), 6-311++G(3df, 3pd) and aug-cc-pVDZ]. Change of the tautomeric preference was observed when going from the neutral to ionized tautomeric mixture. Ionization favors the enolization process (ketoenol) of pyruvic acid, whereas the ketonization (ketoenol) is preferred ...
متن کاملAssociation of IL-10 rs1800896 (-1082 G/A) gene polymorphism and susceptibility to rheumatoid arthritis (RA) in Northeast of Iran
Background and objectives: Rheumatoid arthritis (RA) is a complex and systemic inflammatory disease in which the immune response is disturbed. Single nucleotide polymorphisms (SNPs) in the promoter regions of regulatory cytokines including interleukin-10 (IL-10) may lead to exacerbated immune response and increased risk of RA. Here, we aimed to assess the association of IL-10 -1082 (G/A) (rs180...
متن کاملEfficiency of BclI Restriction Fragment Length Polymorphism for Detection of Hemophilia A Carriers in Sistan and Baluchestan Province, Southeast of Iran
Background: Indirect genetic diagnosis using polymorphic DNA markers can detect carriers of hemophilia A. This technique is preferable in developing countries because of its simplicity and cost effectiveness compared to direct mutation analysis. In the present study, we examined usefulness of intragenic marker BclI restriction fragment length polymorphism (RFLP) at intron 18, for carrier detect...
متن کاملGenetic Variation Among Salvia Species Based on Sequence-Related Amplified Polymorphism (SRAP) Marker
In this study, SRAP molecular maker approach was performed to investigate genetic diversity in the Salvia genus. A total of 205 DNA bands were produced from PCR amplification of 11 Salvia species and populations using 25 selective primer combinations, of which 204 polymorphic genetic loci accounted. The total number of amplified fragments ranged from 3 to 15. The genetic similarities of 11 coll...
متن کاملAssociation of Two Polymorphic Codons in P53 and ABCC1 Promoter with Prostate Cancer
Background: In prostate cancer, mutated p53 alleles typically contain missense single-base substitution in codon 72 that resides within exons 5-8. Stable p53 proteins in tumor cell nuclei have been associated with malignancy. A role of p53 is the regulation of drug transporters like ABCC1 (MRP1) by an effect on promoter region. Objectives: The objective of this study was to identify association...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Chemical communications
دوره 48 85 شماره
صفحات -
تاریخ انتشار 2012